Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Abstract 22q11. 2 deletion syndrome (22q11DS) is a highly penetrant and common genetic
cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from …

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with
diabetes. The mechanisms mediating DNP are not completely elucidated, and effective …

Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt
ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via …

Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic
episodes that affect 2% of the world population. The first-line long-term treatment for mood …

Rationale: During neonatal heart regeneration, the fibrotic response, which is required to
prevent cardiac rupture, resolves via poorly understood mechanisms. Deletion of the Hippo …

Highlights•LTP induction promotes the localization of Wnt7a/b protein at dendritic
spines.•Wnt-Frizzled signaling is required for NMDA receptor-dependent LTP.•Wnt7a …

The Hippo and Wnt signalling pathways play crucial roles in maintaining tissue homeostasis
and organ size by orchestrating cell proliferation, differentiation and apoptosis. These …

The structural and functional plasticity of synapses is critical for learning and memory. Long-
term potentiation (LTP) induction promotes spine growth and AMPAR accumulation at …