Current therapy for chronic hepatitis C: The role of direct-acting antivirals

G Li, E De Clercq - Antiviral research, 2017 - Elsevier
One of the most exciting developments in antiviral research has been the discovery of the
direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections …

EASL recommendations on treatment of hepatitis C: final update of the series☆

JM Pawlotsky, F Negro, A Aghemo, M Berenguer… - Journal of …, 2020 - Elsevier
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, with
approximately 71 million chronically infected individuals worldwide. Clinical care for patients …

[HTML][HTML] Non-epidemic HCV genotypes in low-and middle-income countries and the risk of resistance to current direct-acting antiviral regimens

R Shah, L Ahovegbe, M Niebel, J Shepherd… - Journal of …, 2021 - Elsevier
The hepatitis C virus (HCV) is an extremely diverse virus, subtypes of which are distributed
variably around the world. Viral genotypes may be divided into epidemic subtypes; those …

Identification of a novel hepatitis C virus genotype from Punjab, India: expanding classification of hepatitis C virus into 8 genotypes

SM Borgia, C Hedskog, B Parhy… - The Journal of …, 2018 - academic.oup.com
Abstract Background Hepatitis C virus (HCV) exhibits great genetic diversity and is classified
into 7 genotypes (GTs), with varied geographic prevalence. Until the recent development of …

Identification of 19 novel hepatitis C virus subtypes—further expanding HCV classification

C Hedskog, B Parhy, S Chang… - Open forum …, 2019 - academic.oup.com
Abstract Background Hepatitis C virus (HCV) is currently classified into 8 genotypes and 86
subtypes. The objective of this study was to characterize novel HCV subtypes and to …

Global epidemiology of HCV subtypes and resistance-associated substitutions evaluated by sequencing-based subtype analyses

TM Welzel, N Bhardwaj, C Hedskog… - Journal of …, 2017 - Elsevier
Background & Aims HCV genotype, subtype, and presence of resistance-associated
substitutions (RASs) are key determinants for the selection of direct-acting antiviral (DAA) …

Resistance analysis in patients with genotype 1–6 HCV infection treated with sofosbuvir/velpatasvir in the phase III studies

C Hezode, N Reau, ES Svarovskaia, BP Doehle… - Journal of …, 2018 - Elsevier
Background & Aims The fixed-dose combination of sofosbuvir/velpatasvir was highly
efficacious in patients infected with genotype (GT) 1–6 hepatitis C virus (HCV) in the …

A potent human neutralizing antibody Fc-dependently reduces established HBV infections

D Li, W He, X Liu, S Zheng, Y Qi, H Li, F Mao, J Liu… - Elife, 2017 - elifesciences.org
Hepatitis B virus (HBV) infection is a major global health problem. Currently-available
therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D …

Viral hepatitis C therapy: pharmacokinetic and pharmacodynamic considerations: a 2019 update

EJ Smolders, AME Jansen, PGJ Ter Horst… - Clinical …, 2019 - Springer
It has been estimated by the World Health Organization (WHO) that over 71 million people
were infected with the hepatitis C virus (HCV) in 2015. Since then, a number of highly …

[PDF][PDF] Highly diverse Hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments

C Davis, GS Mgomella, A da Silva Filipe, EH Frost… - …, 2019 - Wiley Online Library
The global plan to eradicate hepatitis C virus (HCV) led by the World Health Organization
outlines the use of highly effective direct‐acting antiviral drugs (DAAs) to achieve elimination …