ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration

C Feng, M Yang, M Lan, C Liu, Y Zhang… - Oxidative medicine …, 2017 - Wiley Online Library
Excessive reactive oxygen species (ROS) generation in degenerative intervertebral disc
(IVD) indicates the contribution of oxidative stress to IVD degeneration (IDD), giving a novel …

Mitochondrial dysfunction in oxidative stress‐mediated intervertebral disc degeneration

DK Wang, HL Zheng, WS Zhou, ZW Duan… - Orthopaedic …, 2022 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain
(LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) …

[HTML][HTML] Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

Y Song, S Li, W Geng, R Luo, W Liu, J Tu, K Wang… - Redox biology, 2018 - Elsevier
Intervertebral disc (IVD) degeneration contributes largely to pathoanatomical and
degenerative changes of spinal structure that increase the risk of low back pain. Apoptosis in …

[HTML][HTML] The PI3K/Akt pathway: a critical player in intervertebral disc degeneration

ZH Ouyang, WJ Wang, YG Yan, B Wang, GH Lv - Oncotarget, 2017 - ncbi.nlm.nih.gov
Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a
severe public health problem worldwide. Current therapy for IDD aims to alleviate the …

Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative …

Q Yu, F Han, Z Yuan, Z Zhu, C Liu, Z Tu, Q Guo… - Acta Biomaterialia, 2022 - Elsevier
Tissue engineering holds potential in the treatment of intervertebral disc degeneration (IDD).
However, implantation of tissue engineered constructs may cause foreign body reaction and …

The role of ageing and oxidative stress in intervertebral disc degeneration

P Wen, B Zheng, B Zhang, T Ma, L Hao… - Frontiers in Molecular …, 2022 - frontiersin.org
Intervertebral disc degeneration (IDD) is the primary cause of intervertebral disc (IVD)
disease. With the increased ageing of society, an increasing number of patients are plagued …

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights

Q Xiang, Y Zhao, J Lin, S Jiang, W Li - Experimental & molecular …, 2022 - nature.com
Intervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder
and is recognized as a major contributor to discogenic lower back pain. However, the …

[HTML][HTML] Regulated cell death: implications for intervertebral disc degeneration and therapy

F Yang, W Liu, Y Huang, S Yang, Z Shao, X Cai… - Journal of Orthopaedic …, 2022 - Elsevier
As a controllable biological process, regulated cell death (RCD) extensively participates in
cellular homeostasis, organismal development, and the pathogenesis of diseases. This …

Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma

X Cai, Y Liu, W Yang, Y Xia, C Yang… - Journal of …, 2016 - Wiley Online Library
Recent studies have revealed that long noncoding RNA metastasis‐associated lung
adenocarcinoma transcript 1 (MALAT1) plays an important role in the development of …

Molecular mechanisms of intervertebral disc degeneration

SM Rider, S Mizuno, JD Kang - Spine surgery and related research, 2019 - jstage.jst.go.jp
Intervertebral disc degeneration is a well-known cause of disability, the result of which
includes neck and back pain with associated mobility limitations. The purpose of this article …