Curcumin analogues and their hybrid molecules as multifunctional drugs

SA Noureddin, RM El-Shishtawy, KO Al-Footy - European journal of …, 2019 - Elsevier
Abstract Curcumin (diferuloylmethane or 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-
heptadiene-3, 5-dione) is an interesting compound that is characterized by a special …

Targeted regulated cell death with small molecule compounds in colorectal cancer: Current perspectives of targeted therapy and molecular mechanisms

R Li, Y Wu, Y Li, W Shuai, A Wang, Y Zhu, X Hu… - European Journal of …, 2024 - Elsevier
Colorectal cancer (CRC), a tumor of the digestive system, is characterized by high
malignancy and poor prognosis. Currently, targeted therapy of CRC is far away from …

An overview of structure–activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents

L Arshad, MA Haque, SN Abbas Bukhari… - Future medicinal …, 2017 - Taylor & Francis
Curcumin, extracted mainly from Curcuma longa rhizomes, has been reported to possess
potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and …

Immunosuppressive effects of natural α, β-unsaturated carbonyl-based compounds, and their analogs and derivatives, on immune cells: a review

L Arshad, I Jantan, SNA Bukhari… - Frontiers in …, 2017 - frontiersin.org
The immune system is complex and pervasive as it functions to prevent or limit infections in
the human body. In a healthy organism, the immune system and the redox balance of …

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

PY Khor, MFFM Aluwi, K Rullah, KW Lam - European journal of medicinal …, 2019 - Elsevier
Curcumin is a small organic molecule with pleiotropic biological activities. However, its
multiple structural-pharmacokinetic challenges prevent its development into a clinical drug …

Novel α‐Mangostin Derivatives from Mangosteen (Garcinia mangostana L.) Peel Extract with Antioxidant and Anticancer Potential

VA Tran, TT Thi Vo, MNT Nguyen… - Journal of …, 2021 - Wiley Online Library
The mangosteen peels contain biologically active compounds, with antioxidant and
anticancer properties. Among these isolated phytochemicals, α‐mangostin is one of the …

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human …

MFFM Aluwi, K Rullah, BM Yamin, SW Leong… - Bioorganic & medicinal …, 2016 - Elsevier
The syntheses and bioactivities of symmetrical curcumin and its analogues have been the
subject of interest by many medicinal chemists and pharmacologists over the years. To …

Synthesis and molecular docking of N′-arylidene-5-(4-chlorophenyl)-1-(3, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbohydrazides as novel hypoglycemic and …

E Hernández-Vázquez, S Salgado-Barrera… - Bioorganic & medicinal …, 2016 - Elsevier
Herein, the design and synthesis of 10 novel N′-arylidene pyrazole-3-carbohydrazides are
described. Compounds were pretended to act as dual agents against diabetes and oxidative …

Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships

J Moreira, L Saraiva, MM Pinto, H Cidade - Molecules, 2022 - mdpi.com
Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …

Preparation, characterization and antioxidant evaluation of poorly soluble polyphenol-loaded nanoparticles for cataract treatment

D Vora, S Heruye, D Kumari, C Opere, H Chauhan - AAPS PharmSciTech, 2019 - Springer
Cataract, one of the leading causes of blindness worldwide, is a condition in which complete
or partial opacity develops in the lens of the eyes, thereby impairing vision. This study aimed …