Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

Two different forms of death are commonly observed when Mycobacterium tuberculosis
(Mtb)-infected macrophages die:(i) necrosis, a death modality defined by cell lysis and (ii) …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains the leading cause
of mortality from a single infectious agent. Each year around 9 million individuals newly …

Abstract Virulent Mycobacterium tuberculosis (Mtb) inhibits apoptosis and triggers necrosis
of host macrophages to evade innate delay in the initiation of adaptive immunity. Necrosis is …

Owing to our lack of understanding of the factors that constitute protective immunity during
natural infection with Mycobacterium tuberculosis (Mtb), there is an urgent need to identify …

Cytokine gene single nucleotide polymorphisms (SNPs) can influence cytokine levels, which
may be associated with tuberculosis (TB) susceptibility. There is evidence that interleukin 1B …

The molecular basis of pathogen-induced host cell apoptosis is well characterized for a
number of microorganisms. Mycobacterium tuberculosis is known to induce apoptosis and it …

It has been clearly demonstrated that in vitro, virulent M. tuberculosis can favor necrosis over
apoptosis in infected macrophages, and this has been suggested as a mechanism for …

Determining what constitutes protective immunity to TB is critical for the development of
improved diagnostics and vaccines. The comparison of the immune system between …

Background. A major barrier to effective tuberculosis control is our limited understanding of
risk factors for tuberculosis disease progression. This study examined the role of apoptosis …