Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable
increase in the risk for this disease after menopause and typically develop coronary heart …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …

Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …

Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Functional genomics data has the potential to increase GWAS power by identifying SNPs
that have a higher prior probability of association. Here, we introduce a method that …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …