The search for novel treatment strategies for Streptococcus pneumoniae infections

F Cools, P Delputte, P Cos - FEMS Microbiology Reviews, 2021 - academic.oup.com
This review provides an overview of the most important novel treatment strategies against
Streptococcus pneumoniae infections published over the past 10 years. The pneumococcus …

Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

M Ud-Din, A Albutti, A Ullah, S Ismail, S Ahmad… - International Journal of …, 2022 - mdpi.com
Antibiotic resistance (AR) is the result of microbes' natural evolution to withstand the action
of antibiotics used against them. AR is rising to a high level across the globe, and novel …

Towards A Novel Multi-Epitopes Chimeric Vaccine for Simulating Strong Immune Responses and Protection against Morganella morganii

A Ullah, S Ahmad, S Ismail, Z Afsheen… - International Journal of …, 2021 - mdpi.com
Morganella morganii is one of the main etiological agents of hospital-acquired infections
and no licensed vaccine is available against the pathogen. Herein, we designed a multi …

Pan-genome analysis of oral bacterial pathogens to predict a potential novel multi-epitopes vaccine candidate

T Rida, S Ahmad, A Ullah, S Ismail… - International Journal of …, 2022 - mdpi.com
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium, mainly present in the
oral cavity and causes periodontal infections. Currently, no licensed vaccine is available …

Vaccinomics to design a novel single chimeric subunit vaccine for broad-spectrum immunological applications targeting nosocomial Enterobacteriaceae pathogens

S Ismail, S Ahmad, SS Azam - European Journal of Pharmaceutical …, 2020 - Elsevier
Healthcare associated infections (HAIs) are major cause of elevated mortality, morbidity, and
high healthcare costs. Development of a vaccine targeting these pathogens could benefit in …

Combating tigecycline resistant Acinetobacter baumannii: A leap forward towards multi-epitope based vaccine discovery

S Ahmad, KE Ranaghan, SS Azam - European Journal of Pharmaceutical …, 2019 - Elsevier
Global emergence of Tigecycline resistant Acinetobacter baumannii (TRAB) is on the
horizon and poses a very serious threat to human health. There is a pressing demand for …

An integrated computational framework to design a multi-epitopes vaccine against Mycobacterium tuberculosis

A Albutti - Scientific Reports, 2021 - nature.com
Tuberculosis (TB) is a highly contagious disease that mostly affects the lungs and is caused
by a bacterial pathogen, Mycobacterium tuberculosis. The associated mortality rate of TB is …

[HTML][HTML] An integrated in silico based subtractive genomics and reverse vaccinology approach for the identification of novel vaccine candidate and chimeric vaccine …

K Khan, K Jalal, R Uddin - Genomics, 2022 - Elsevier
Salmonella typhi is notorious for causing enteric fever which is also known as typhoid fever.
It emerged as an extreme drug resistant strain that requires urgent attention to prevent its …

Gallic acid potentiates the antimicrobial activity of tulathromycin against two key bovine respiratory disease (BRD) causing-pathogens

K Rajamanickam, J Yang, MK Sakharkar - Frontiers in pharmacology, 2019 - frontiersin.org
Bovine respiratory disease (BRD) is the most common infectious disease in dairy and beef
cattle. It is associated with significant morbidity and mortality and causes a huge economic …

[HTML][HTML] Core proteome mediated therapeutic target mining and multi-epitope vaccine design for Helicobacter pylori

N Rahman, A Ajmal, F Ali, L Rastrelli - Genomics, 2020 - Elsevier
Helicobacter pylori is a Gram-negative spiral-shaped bacterium that infects half of the
human population worldwide and causes chronic inflammation. In the present study, we …