Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations

RA Somoza, JF Welter, D Correa… - Tissue Engineering Part …, 2014 - liebertpub.com
Articular cartilage repair and regeneration provides a substantial challenge in Regenerative
Medicine because of the high degree of morphological and mechanical complexity intrinsic …

Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives

HD Zomer, AS Vidane, NN Goncalves… - Stem cells and cloning …, 2015 - Taylor & Francis
Mesenchymal stem cells have awakened a great deal of interest in regenerative medicine
due to their plasticity, and immunomodulatory and anti-inflammatory properties. They are …

[HTML][HTML] Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells

J Frobel, H Hemeda, M Lenz, G Abagnale, S Joussen… - Stem cell reports, 2014 - cell.com
Standardization of mesenchymal stromal cells (MSCs) remains a major obstacle in
regenerative medicine. Starting material and culture expansion affect cell preparations and …

[HTML][HTML] Exosomes from human-induced pluripotent stem cell–derived mesenchymal stromal cells (hiPSC-MSCs) protect liver against hepatic ischemia/reperfusion …

Y Du, D Li, C Han, H Wu, L Xu, M Zhang… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: This study aimed to evaluate the effects of exosomes produced by human-
induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs-Exo) on …

The future of mesenchymal stem cell-based therapeutic approaches for cancer–from cells to ghosts

A Mohr, R Zwacka - Cancer letters, 2018 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent stromal cells which can differentiate into a
variety of cell types including osteoblasts, adipocytes and chondrocytes. They are normally …

Concise review: mesenchymal stem cells derived from human pluripotent cells, an unlimited and quality-controllable source for therapeutic applications

B Jiang, L Yan, X Wang, E Li, K Murphy, K Vaccaro… - Stem …, 2019 - academic.oup.com
Despite the long discrepancy over their definition, heterogeneity, and functions,
mesenchymal stem cells (MSCs) have proved to be a key player in tissue repair and …

Human induced pluripotent stem cells differentiate into functional mesenchymal stem cells and repair bone defects

D Sheyn, S Ben-David, G Shapiro… - Stem cells …, 2016 - academic.oup.com
Mesenchymal stem cells (MSCs) are currently the most established cells for skeletal tissue
engineering and regeneration; however, their availability and capability of self-renewal are …

Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)

N Prakash, J Kim, J Jeon, S Kim, Y Arai… - Biomaterials …, 2023 - spj.science.org
The use of mesenchymal stem cells (MSCs) for clinical purposes has skyrocketed in the past
decade. Their multilineage differentiation potentials and immunomodulatory properties have …

Generation of functional mesenchymal stem cells from different induced pluripotent stem cell lines

K Hynes, D Menicanin, K Mrozik… - Stem cells and …, 2014 - liebertpub.com
The therapeutic potential of mesenchymal stem cells (MSC) has highlighted the need for
identifying easily accessible and reliable sources of these cells. An alternative source for …

[HTML][HTML] Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion …

X Yuan, D Li, X Chen, C Han, L Xu, T Huang… - Cell death & …, 2017 - nature.com
Renal ischemia-reperfusion is a main cause of acute kidney injury (AKI), which is associated
with high mortality. Here we show that extracellular vesicles (EVs) secreted from hiPSC …