The development of coronary artery disease, and specifically myocardial infarction, involves
hyperplasia of arterial smooth muscle, the development of fatty streaks, atheroma formation …

The link between plasminogen activator inhibitor (PAI)-1 and the metabolic syndrome with
obesity was established many years ago. Increased PAI-1 level can be now considered a …

C-reactive protein (CRP) is a liver-derived pattern recognition molecule that is increased in
inflammatory states. It rapidly increases within hours after tissue injury, and it is suggested …

Hyperinsulinemia is associated with the development of coronary heart disease. However,
the underlying mechanisms are still poorly understood. Hypercoagulability and impaired …

Accelerated atherosclerosis is the leading cause of death in patients with non-insulin-
dependent diabetes mellitus (NIDDM). Impaired endogenous fibrinolytic activity may …

Decreased plasma fibrinolysis may contribute to accelerated atherothrombosis in diabetes.
To observe whether hyperglycemia and hyperinsulinemia, common findings in type 2 …

Atherosclerotic plaque rupture and erosions precipitate thrombus formation and may lead to
an acute ischemic syndrome. Lipids and lipoproteins modulate the expression and/or …

Sixteen nondiabetic women with polycystic ovary syndrome (PCOS) aged 18 to 33 years
were studied before and after 8 weeks on metformin (1.5 g/d) therapy to assess whether …

Atherosclerosis is a leading cause of morbidity and mortality in populations around the
world. The clustering of risk factors for atherosclerosis, such as abnormal glucose tolerance …

Clinical manifestations of coronary heart disease result principally from the progressive
development of atherosclerotic plaques and subsequent thrombus formation. The role of …