Antifungal drug resistance: an emergent health threat

A Vitiello, F Ferrara, M Boccellino, A Ponzo, C Cimmino… - Biomedicines, 2023 - mdpi.com
Fungal infections, named mycosis, can cause severe invasive and systemic diseases that
can even lead to death. In recent years, epidemiological data have recorded an increase in …

Emerging antifungal targets and strategies

M Ivanov, A Ćirić, D Stojković - International Journal of Molecular …, 2022 - mdpi.com
Despite abundant research in the field of antifungal drug discovery, fungal infections remain
a significant healthcare burden. There is an emerging need for the development of novel …

New roads leading to old destinations: efflux pumps as targets to reverse multidrug resistance in bacteria

G Spengler, A Kincses, M Gajdács, L Amaral - Molecules, 2017 - mdpi.com
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

A Rosenberg, IV Ene, M Bibi, S Zakin, ES Segal… - Nature …, 2018 - nature.com
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

Dermatophyte resistance to antifungal drugs: mechanisms and prospectus

NM Martinez-Rossi, TA Bitencourt, NTA Peres… - Frontiers in …, 2018 - frontiersin.org
Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized
structures present in nails, skin, and hair, causing superficial infections known as …

The role of eukaryotic and prokaryotic ABC transporter family in failure of chemotherapy

R El-Awady, E Saleh, A Hashim, N Soliman… - Frontiers in …, 2017 - frontiersin.org
Over the years chemotherapy failure has been a vital research topic as researchers have
been striving to discover reasons behind it. The extensive studies carried out on …

Targeting antimicrobial drug resistance with marine natural products

F Barbosa, E Pinto, A Kijjoa, M Pinto… - International journal of …, 2020 - Elsevier
The rise and spread of antimicrobial resistance represents one of the most pressing health
issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of …

[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi

MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

KR Iyer, K Camara, M Daniel-Ivad, R Trilles… - Nature …, 2020 - nature.com
Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs,
including the most commonly prescribed antifungal, fluconazole. Here, we use a …

Fungal drug response and antimicrobial resistance

P Osset-Trénor, A Pascual-Ahuir, M Proft - Journal of Fungi, 2023 - mdpi.com
Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …