Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a
critical variable in human health and physiology, but its trajectory over the life course is …

To date, nutritional epidemiology has relied heavily on relatively weak methods including
simple observational designs and substandard measurements. Despite low internal validity …

ABSTRACT The ASN Board of Directors appointed the Nutrition Research Task Force to
develop a report on scientific methods used in nutrition science to advance discovery …

Morning loaded calorie intake in humans has been advocated as a dietary strategy to
improve weight loss. This is also supported by animal studies suggesting time of eating can …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Understanding the impacts of activity on energy balance is crucial. Increasing levels of
activity may bring diminishing returns in energy expenditure because of compensatory …

Importance Short sleep duration has been recognized as a risk factor for obesity. Whether
extending sleep duration may mitigate this risk remains unknown. Objective To determine …

The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by
recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses …

Background Physical activity (PA) during pregnancy is an effective and safe way to improve
maternal health in uncomplicated pregnancies. However, compliance with PA …

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight
gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is …