Pirfenidone (PFN) is an anti-fibrotic drug with significant anti-inflammatory property used for
treatment of fibrotic conditions such as idiopathic pulmonary fibrosis (IPF). In the coronavirus …

Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …

In the era of antimicrobial resistance, the prevalence of multidrug-resistant microorganisms
that resist conventional antibiotic treatment has steadily increased. Thus, it is now …

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …

This study investigated the effect of melatonin on clinical outcomes in patients with
coronavirus disease 2019 (COVID‐19). We searched PubMed, the Web of Science, the …

Melatonin is registered to treat circadian rhythm sleep–wake disorders and insomnia in
patients aged 55 years and over. The essential role of the circadian sleep rhythm in the …

Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger
for months beyond the acute stage of SARS-CoV-2 infection,“long COVID”. Among the long …

Sepsis is one of the main causes of death in critically ill patients. Despite the continuous
development of medical technology in recent years, its morbidity and mortality are still high …

Since the beginning of the COVID-19 pandemic, older adults have been found to be a highly
vulnerable group, with a higher prevalence of severe cases and negative outcomes …

Machine Learning (ML) is an algorithm based on big data, which learns patterns from the
previously observed data through classifying, predicting, and optimizing to accomplish …