Origin of viruses: primordial replicators recruiting capsids from hosts
Viruses are ubiquitous parasites of cellular life and the most abundant biological entities on
Earth. It is widely accepted that viruses are polyphyletic, but a consensus scenario for their …
Earth. It is widely accepted that viruses are polyphyletic, but a consensus scenario for their …
The LUCA and its complex virome
The last universal cellular ancestor (LUCA) is the most recent population of organisms from
which all cellular life on Earth descends. The reconstruction of the genome and phenotype …
which all cellular life on Earth descends. The reconstruction of the genome and phenotype …
Diversity and evolution of B-family DNA polymerases
B-family DNA polymerases (PolBs) represent the most common replicases. PolB enzymes
that require RNA (or DNA) primed templates for DNA synthesis are found in all domains of …
that require RNA (or DNA) primed templates for DNA synthesis are found in all domains of …
[HTML][HTML] Mechanism of primer synthesis by Primase-Polymerases
K Zabrady, AWH Li, AJ Doherty - Current Opinion in Structural Biology, 2023 - Elsevier
Members of the primase-polymerase (Prim-Pol) superfamily are found in all domains of life
and play diverse roles in genome stability, including primer synthesis during DNA …
and play diverse roles in genome stability, including primer synthesis during DNA …
Reclassification of family A DNA polymerases reveals novel functional subfamilies and distinctive structural features
D Czernecki, A Nourisson, P Legrand… - Nucleic Acids …, 2023 - academic.oup.com
Abstract Family A DNA polymerases (PolAs) form an important and well-studied class of
extant polymerases participating in DNA replication and repair. Nonetheless, despite the …
extant polymerases participating in DNA replication and repair. Nonetheless, despite the …
[HTML][HTML] Candidatus Nitrosocaldus cavascurensis, an ammonia oxidizing, extremely thermophilic archaeon with a highly mobile genome
Ammonia oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread in
moderate environments but their occurrence and activity has also been demonstrated in hot …
moderate environments but their occurrence and activity has also been demonstrated in hot …
How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
Bacteriophages have long been known to use modified bases in their DNA to prevent
cleavage by the host's restriction endonucleases. Among them, cyanophage S-2L is unique …
cleavage by the host's restriction endonucleases. Among them, cyanophage S-2L is unique …
Going to extremes–a metagenomic journey into the dark matter of life
A Aevarsson, AK Kaczorowska… - FEMS microbiology …, 2021 - academic.oup.com
ABSTRACT The Virus-X—Viral Metagenomics for Innovation Value—project was a scientific
expedition to explore and exploit uncharted territory of genetic diversity in extreme natural …
expedition to explore and exploit uncharted territory of genetic diversity in extreme natural …
The replication machinery of LUCA: common origin of DNA replication and transcription
EV Koonin, M Krupovic, S Ishino, Y Ishino - BMC biology, 2020 - Springer
Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs)
are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The …
are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The …
Archaeal DNA replication
MD Greci, SD Bell - Annual review of microbiology, 2020 - annualreviews.org
It is now well recognized that the information processing machineries of archaea are far
more closely related to those of eukaryotes than to those of their prokaryotic cousins, the …
more closely related to those of eukaryotes than to those of their prokaryotic cousins, the …