[HTML][HTML] Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss

K Xu, B Xu, J Gu, X Wang, D Yu, Y Chen - Theranostics, 2023 - ncbi.nlm.nih.gov
Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

Unveiling the Role of Oxidative Stress in Cochlear Hair Cell Death: Prospective Phytochemical Therapeutics against Sensorineural Hearing Loss

NB Gill, PD Dowker-Key, M Hedrick… - International Journal of …, 2024 - mdpi.com
Hearing loss represents a multifaceted and pervasive challenge that deeply impacts various
aspects of an individual's life, spanning psychological, emotional, social, and economic …

Intratympanic injections of emulsion-like dispersions to augment cinnarizine amount in a healthy rabbit inner ear model

A Goswami, SN Ruhina Rahman, S Ponneganti… - …, 2024 - Taylor & Francis
Aim: To investigate eutectic liquid-based emulsion-like dispersions for intratympanic
injections to augment cinnarizine permeability across round window membrane in a healthy …

2D Catalytic Niobium Carbide MXenzyme for Ameliorating Noise‐Induced Hearing Loss

B Xu, Q Jiang, Y Huang, K Xu, W Feng… - Advanced Functional …, 2024 - Wiley Online Library
Noise‐induced hearing loss (NIHL), a prevalent sensory disability affecting a majority of the
global population, is dominantly induced by mitochondrial dysfunction and oxidative stress …

Phototoxic potential of different DNA intercalators for skin cancer therapy: In vitro screening

TP Pivetta, T Vieira, JC Silva, PA Ribeiro… - International Journal of …, 2023 - mdpi.com
Photodynamic therapy is a minimally invasive procedure used in the treatment of several
diseases, including some types of cancer. It is based on photosensitizer molecules, which, in …

Gelatin‐Encapsulated Tetrahedral DNA Nanostructure Enhances Cellular Internalization for Treating Noise‐Induced Hearing Loss

K Xu, Y Du, B Xu, Y Huang, W Feng, D Yu, Y Chen… - Small, 2024 - Wiley Online Library
Nanoparticle‐based drug delivery strategies have emerged as a crucial avenue for
comprehensive sensorineural hearing loss treatment. Nevertheless, developing therapy …

Programmable NIR Responsive Nanocomposite Enables Noninvasive Intratympanic Delivery of Dexamethasone to Reverse Cisplatin Induced Hearing Loss

RA Mustafa, J Wang, M Xun, JM Rosenholm… - Advanced …, 2024 - Wiley Online Library
Local intratympanic drug delivery to the inner ear possesses significant otological clinical
promise as cisplatin‐induced hearing loss (CIHL) therapy, inducing significantly less side …

Sound conditioning strategy promoting paracellular permeability of the blood‐labyrinth‐barrier benefits inner ear drug delivery

X Wang, J Gu, K Xu, B Xu, D Yu… - … & Translational Medicine, 2024 - Wiley Online Library
The therapeutic effects of pharmaceuticals depend on their drug concentrations in the
cochlea. Efficient drug delivery from the systemic circulation into the inner ear is limited by …

Intratympanic injections made from eutectic liquid (camphor and menthol)-based oil-less emulsions containing morin hydrate-lipoid E80 complex: An approach to …

A Goswami, CA Shafik, A Das, S Ponneganti… - Journal of Drug Delivery …, 2024 - Elsevier
Morin hydrate (MH, flavonols of plants, family-Moraceae) promotes inner ear stem cell
survival and differentiation process to preserve the healthy hearing function. However, round …

Biomaterials as New Option for Treating Sensorineural Hearing Loss

L Wang, R Zhang, L Jiang, S Gao, J Wu, Y Jiao - Biomaterials Science, 2024 - pubs.rsc.org
Sensorineural hearing loss (SNHL) usually involves damage to complex auditory pathways
such as inner ear cells and auditory nerves. The highly intricate and nuanced characteristics …