Small molecule inhibitors that selectively target cancer cells and not normal cells would be
valuable anti-cancer therapeutics. The mammalian target of rapamycin complex 2 …

Research on TOR has grown exponentially during the last decade, generating a complex
model of the TOR signaling network. Rapamycin treatment provides a simple and …

The mammalian target of rapamycin (mTOR) functions within two distinct complexes
(mTORC1 and mTORC2) to control cell growth, proliferation, survival, and metabolism …

Mammalian target of rapamycin (mTOR) is a member of the phosphatidylinositol 3-kinase-
related kinase (PIKK) family and is a major regulator of translation, cell growth, and …

mTORC2 (mammalian target of rapamycin complex 2) plays important roles in signal
transduction by regulating an array of downstream effectors, including protein kinase AKT …

TEL2 interacts with and is essential for the stability of all phosphatidylinositol 3-kinase-
related kinases (PIKKs), but its mechanism of action remains unclear. Here, we show that …

In response to DNA damage, cells activate a complex signal transduction network called the
DNA damage response (DDR). To enhance our current understanding of the DDR network …

Germline apoptosis shares with somatic apoptosis a reliance on key components of the core
apoptotic machinery, including CED-3 and CED-4. However, germline apoptosis differs from …

We reported previously that the stability of all mammalian phosphatidylinositol 3-kinase-
related protein kinases (PIKKs) depends on their interaction with Tel2, the ortholog of yeast …

Abstract The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone
complex involved in the assembly of a number of critical protein complexes including …