Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …

Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …

The optic nerve, like most pathways in the mature central nervous system, cannot
regenerate if injured, and within days, retinal ganglion cells (RGCs), the neurons that extend …

The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide
range of internal and external cellular stress signals. Beside the stress response, the JNK …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Neurons in the central nervous system (CNS) are terminally differentiated cells that
gradually lose their ability to support regeneration during maturation due to changes in …