Adipose tissue is an immunologically active organ that controls host physiology, partly
through the release of mediators termed adipokines. In obesity, adipocytes and infiltrating …

Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which
is due to delayed diagnosis and resistance to current therapies. The interactions between …

The signals and structure of the tissues in which leukocytes reside critically mould leukocyte
function and development and have challenged our fundamental understanding of how to …

Polycystic ovary syndrome (PCOS) affects approximately 15% of women of reproductive age
worldwide. It is the most prevalent endocrine disorder with marked risks for female infertility …

Hyperglycemia, a hallmark of diabetes and various metabolic disorders, has profound
implications for immune cell function. The relationship between elevated blood glucose …

Leptin is associated with cardiometabolic complications of obesity, such as metabolic
syndrome and atherosclerosis. In obese men, the presence of metabolic syndrome is …

Obesity-related glomerulopathy, which is an obesity-triggered kidney damage, has become
a significant threat to human health. Several studies have recently highlighted the critical …

Obesity is associated with increased ovarian inflammation and the establishment of leptin
resistance. We presently investigated the role of impaired leptin signalling on transcriptional …

Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease
(MASLD), metabolic and metabolic dysfunction-associated alcoholic liver disease (MetALD) …

Objectives Apical periodontitis (AP) is an inflammatory immune response in periapical
tissues caused by microbial infections. Failure of root canal treatment or delayed healing is …