Environmental enrichment, alone or in combination with various pharmacotherapies, confers marked benefits after traumatic brain injury

PB de la Tremblaye, JP Cheng, CO Bondi, AE Kline - Neuropharmacology, 2019 - Elsevier
Traumatic brain injury (TBI) is a significant health care issue that affects over ten million
people worldwide. Treatment options are limited with numerous failures resulting from single …

The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test

PJ Fitzgerald, PJ Hale, A Ghimire, BO Watson - Translational psychiatry, 2020 - nature.com
Finding new antidepressant agents is of high clinical priority given that many cases of major
depressive disorder (MDD) do not respond to conventional monoaminergic antidepressants …

Enriched environment as a nonpharmacological neuroprotective strategy

A Vaquero-Rodríguez, N Ortuzar… - Experimental …, 2023 - journals.sagepub.com
The structure and functions of the central nervous system are influenced by environmental
stimuli, which also play an important role in brain diseases. Enriched environment (EE) …

Milnacipran ameliorates executive function impairments following frontal lobe traumatic brain injury in male rats: a multimodal behavioral assessment

TJ Craine, NS Race, LA Kutash… - Journal of …, 2023 - liebertpub.com
Traumatic brain injuries (TBIs) affect more than 10 million patients annually worldwide,
causing long-term cognitive and psychosocial impairments. Frontal lobe TBIs commonly …

Chronic treatment with galantamine rescues reversal learning in an attentional set-shifting test after experimental brain trauma

I Njoku, HL Radabaugh, MA Nicholas, LA Kutash… - Experimental …, 2019 - Elsevier
Approximately 10 million new cases of traumatic brain injury (TBI) are reported each year
worldwide with many of these injuries resulting in higher order cognitive impairments …

Evaluating the efficacy of chronic galantamine on sustained attention and cholinergic neurotransmission in a pre-clinical model of traumatic brain injury

EH Moschonas, HE Capeci, EM Annas… - Journal of …, 2024 - liebertpub.com
Cholinergic disruptions underlie attentional deficits following traumatic brain injury (TBI). Yet,
drugs specifically targeting acetylcholinesterase (AChE) inhibition have yielded mixed …

Gait analysis in a rat model of traumatic brain injury

J Reed, A Grillakis, A Kline, AE Ahmed… - Behavioural Brain …, 2021 - Elsevier
Gait disruptions following traumatic brain injury (TBI) are noted in the clinical population. To
date, thorough analysis of gait changes in animal models of TBI to allow for correlation of …

[HTML][HTML] The effect of combination pretreatment of donepezil and environmental enrichment on memory deficits in amyloid-beta-induced Alzheimer-like rat model

J Gholami, SS Negah, A Rajabian, E Saburi… - … and Biophysics Reports, 2022 - Elsevier
Alzheimer's disease (AD) is progressive neurodegeneration known as the most common
cause of dementia, and it is the sixth leading cause of death in older people. Given the …

Environmental modifications to rehabilitate social behavior deficits after acquired brain injury: What is the evidence?

S Bozkurt, NA Lannin, R Mychasiuk… - … & Biobehavioral Reviews, 2023 - Elsevier
Social behavior deficits are a common, debilitating consequence of traumatic brain injury
and stroke, particularly when sustained during childhood. Numerous factors influence the …

Intermittent administration of haloperidol after cortical impact injury neither impedes spontaneous recovery nor attenuates the efficacy of environmental enrichment

GC Bao, IH Bleimeister, LA Zimmerman… - Journal of …, 2019 - liebertpub.com
The administration of haloperidol (HAL) once-daily for 19 days after experimental traumatic
brain injury (TBI) impedes recovery and attenuates the efficacy of environmental enrichment …