Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Biochemical and genetic evidence establishes a central role of the amyloid precursor
protein (APP) in Alzheimer disease (AD) pathogenesis. Biochemically, deposition of the β …

Proteins belonging to the 'A Disintegrin And Metalloproteinase'(ADAM) family are membrane-
anchored proteases that are able to cleave the extracellular domains of several membrane …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

Late‐onset Alzheimer's disease is often connected with nutritional misbalance, such as
enhanced cholesterol intake, deficiency in polyunsaturated fatty acids, or hypovitaminosis …

Various surface molecules undergo regulated cleavage by the disintegrin and
metalloproteinases ADAM10 and ADAM17. The list of substrates includes molecules …

Despite its key role in Alzheimer pathogenesis, the physiological function (s) of the amyloid
precursor protein (APP) and its proteolytic fragments are still poorly understood. Previously …

As a metalloproteinase specialized in releasing membrane-tethered proteins, A Disintegrin
and A Metalloproteinase 17 (ADAM17), also known as Tumor necrosis factor-α Converting …

In the central nervous system (CNS) the function of retinoic acid, the active metabolite of
vitamin A, is best understood from its action in guiding embryonic development; as …

Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions
in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and …