The current status of preclinical proton FLASH radiation and future directions

ES Diffenderfer, BS Sørensen, A Mazal… - Medical …, 2022 - Wiley Online Library
We review the current status of proton FLASH experimental systems, including preclinical
physical and biological results. Technological limitations on preclinical investigation of …

Future developments in charged particle therapy: improving beam delivery for efficiency and efficacy

J Yap, A De Franco, S Sheehy - Frontiers in Oncology, 2021 - frontiersin.org
The physical and clinical benefits of charged particle therapy (CPT) are well recognized.
However, the availability of CPT and complete exploitation of dosimetric advantages are still …

A new emittance selection system to maximize beam transmission for low‐energy beams in cyclotron‐based proton therapy facilities with gantry

V Maradia, D Meer, DC Weber, AJ Lomax… - Medical …, 2021 - Wiley Online Library
Purpose In proton therapy, the potential of using high‐dose rates in the cancer treatment is
being explored. High‐dose rates could improve efficiency and throughput in standard …

[HTML][HTML] Technological basis for clinical trials in FLASH radiation therapy: A review

Y Wu, HJ No, DY Breitkreutz… - Appl Rad …, 2021 - appliedradiationoncology.com
FLASH radiation therapy (RT) has shown potential to increase the therapeutic index for
cancer treatment. In vivo animal studies have shown a differential response between normal …

Monitoring beam charge during FLASH irradiations

B Vojnovic, IDC Tullis, RG Newman… - Frontiers in …, 2023 - frontiersin.org
In recent years, FLASH irradiation has attracted significant interest in radiation research.
Studies have shown that irradiation at ultra-high dose rates (FLASH) reduces the severity of …

Ionizing radiation defects and reliability of Gallium Nitride-based III-V semiconductor devices: a comprehensive review

V Sandeep, JC Pravin, SA Kumar - Microelectronics Reliability, 2024 - Elsevier
The remote sensing and satellite community working for space organizations have
expressed interest in building advanced devices with potential choices for Gallium Nitride …

Recent progress in pencil beam scanning FLASH proton therapy: a narrative review

S Wei, C Shi, CC Chen, S Huang, RH Press… - arXiv preprint arXiv …, 2022 - arxiv.org
Background and Objective: Recent experimental studies using ultra-high dose rate radiation
therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor …

Detailed Monte‐Carlo characterization of a Faraday cup for proton therapy

J Ehwald, M Togno, AJ Lomax, DC Weber… - Medical …, 2023 - Wiley Online Library
Background Experiments with ultra‐high dose rates in proton therapy are of increasing
interest for potential treatment benefits. The Faraday Cup (FC) is an important detector for …

Beam monitor chamber calibration of a synchro-cyclotron high dose rate per pulse pulsed scanned proton beam

M Vidal, A Gérard, V Floquet… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. Ionization chambers, mostly used for beam calibration and for reference
dosimetry, can show high recombination effects in pulsed high dose rate proton beams. The …

Towards clinical application of ultra-high dose rate radiotherapy and the FLASH effect: Challenges and current status

A Chaikh, M Édouard, C Huet, F Milliat, C Villagrasa… - Cancer …, 2024 - Elsevier
Ultra-high dose rate external beam radiotherapy (UHDR-RT) uses dose rates of several tens
to thousands of Gy/s, compared with the dose rate of the order of a few Gy/min for …