Immuno-modulatory effects of intervertebral disc cells

P Bermudez-Lekerika, KB Crump… - Frontiers in cell and …, 2022 - frontiersin.org
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Finite element modeling mesh quality, energy balance and validation methods: A review with recommendations associated with the modeling of bone tissue

TA Burkhart, DM Andrews, CE Dunning - Journal of biomechanics, 2013 - Elsevier
The use of finite element models as research tools in biomechanics and orthopedics has
grown exponentially over the last 20 years. However, the attention to mesh quality, model …

Finite element modeling of soft tissues: material models, tissue interaction and challenges

M Freutel, H Schmidt, L Dürselen, A Ignatius… - Clinical …, 2014 - Elsevier
Background Musculoskeletal soft tissues, such as articular cartilage, ligaments, knee
meniscus and intervertebral disk, have a complex structure, which provides elasticity and …

What have we learned from finite element model studies of lumbar intervertebral discs in the past four decades?

H Schmidt, F Galbusera, A Rohlmann… - Journal of …, 2013 - Elsevier
Finite element analysis is a powerful tool routinely used to study complex biological systems.
For the last four decades, the lumbar intervertebral disc has been the focus of many such …

Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering

DH Cortes, NT Jacobs, JF DeLucca, DM Elliott - Journal of biomechanics, 2014 - Elsevier
The aim of functional tissue engineering is to repair and replace tissues that have a
biomechanical function, ie, connective orthopaedic tissues. To do this, it is necessary to …

Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear …

NT Jacobs, DH Cortes, JM Peloquin, EJ Vresilovic… - Journal of …, 2014 - Elsevier
Finite element (FE) models are advantageous in the study of intervertebral disc mechanics
as the stress–strain distributions can be determined throughout the tissue and the applied …

Effect of hydration on healthy intervertebral disk mechanical stiffness

SE Bezci, A Nandy… - Journal of …, 2015 - asmedigitalcollection.asme.org
The intervertebral disk has an excellent swelling capacity to absorb water, which is thought
to be largely due to the high proteoglycan composition. Injury, aging, degeneration, and …

On the modeling of human intervertebral disc annulus fibrosus: Elastic, permanent deformation and failure responses

F Ghezelbash, A Shirazi-Adl, M Baghani… - Journal of …, 2020 - Elsevier
As a primary load-resisting component, annulus fibrosus (AF) maintains structural integrity of
the entire intervertebral disc. Experiments have demonstrated that permanent deformation …

Comparative biomechanical analysis of rigid vs. flexible fixation devices for the lumbar spine: A geometrically patient-specific poroelastic finite element study

K Khalaf, M Nikkhoo - Computer methods and programs in biomedicine, 2021 - Elsevier
Abstract Background and Objective Lumbar spinal stenosis (LSS), or the narrowing of the
spinal canal, continues to be the leading preoperative diagnosis for adults older than 65 …

Numerical implementation of an osmo-poro-visco-hyperelastic finite element solver: Application to the intervertebral disc

APG Castro, JL Alves - Computer Methods in Biomechanics and …, 2021 - Taylor & Francis
This work deals with the finite element (FE) implementation of a biphasic poroelastic
formulation specifically developed to address the intricate behaviour of the Intervertebral …