Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Parkinson's disease (PD) is the second most common neurodegenerative disease. The
pathogenesis of PD is complicated and remains obscure, but growing evidence suggests …

The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The
mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial …

Mitochondria are essential for neuronal function. They produce ATP to meet energy
demands, regulate homeostasis of ion levels such as calcium and regulate reactive oxygen …

The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the
yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the human CTLH …

Aging, toxic chemicals and changes to the cellular environment are sources of oxidative
damage to mitochondria which contribute to neurodegenerative conditions including …

Neurodegenerative diseases are a broad heterogeneous group affecting the nervous
system. They are characterized, from a pathophysiological perspective, by the selective …

Parkinson's disease (PD) is one of the most prevalent neurodegenerative aging disorders
characterized by motor and non-motor symptoms due to the selective loss of midbrain …

Machado–Joseph disease (MJD) is an autosomal dominant neurodegenerative
spinocerebellar ataxia caused by a polyglutamine-coding CAG repeat expansion in the …

Extracellular vesicles (EVs) are naturally occurring membranous structures secreted by
normal and diseased cells, and carrying a wide range of bioactive molecules. In the central …