Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Cuproptosis: Harnessing transition metal for cancer therapy

W Wang, W Mo, Z Hang, Y Huang, H Yi, Z Sun, A Lei - ACS nano, 2023 - ACS Publications
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Riding the metal wave: A review of the latest developments in metal-based anticancer agents

S Abdolmaleki, A Aliabadi, S Khaksar - Coordination Chemistry Reviews, 2024 - Elsevier
Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …

Harnessing the Power of Gold: Advancements in Anticancer Gold Complexes and functionalized Nanoparticles

MA Malik, AA Hashmi, AS Al-Bogami… - Journal of Materials …, 2024 - pubs.rsc.org
Cancer poses a formidable challenge, necessitating improved treatment strategies. Metal-
based drugs and nanotechnology offer new hope in this battle. Versatile gold complexes …

Metals in cancer research: Beyond platinum metallodrugs

A Casini, A Pöthig - ACS Central Science, 2024 - ACS Publications
The discovery of the medicinal properties of platinum complexes has fueled the design and
synthesis of new anticancer metallodrugs endowed with unique modes of action (MoA) …

1H-1,2,3-Triazol-5-ylidenes as Catalytic Organic Single-Electron Reductants

M Abdellaoui, K Oppel, A Vianna… - Journal of the …, 2024 - ACS Publications
Most of the known single-electron reductants are either metal based reagents, used in a
stoichiometric amount, or a combination of an organic species and a photocatalyst. Here we …

N-Acetylation of Biodegradable Supramolecular Peptide Nanofilaments Selectively Enhances Their Proteolytic Stability for Targeted Delivery of Gold-Based …

Y Marciano, N Nayeem, D Dave, RV Ulijn… - … biomaterials science & …, 2023 - ACS Publications
Peptide materials are promising for various biomedical applications; however, a significant
concern is their lack of stability and rapid degradation in vivo due to non-specific proteolysis …

Protein metalation by medicinal gold compounds: identification of the main features of the metalation process through ESI MS experiments

A Geri, L Massai, L Messori - Molecules, 2023 - mdpi.com
Gold compounds form a new class of promising anticancer agents with innovative modes of
action. It is generally believed that anticancer gold compounds, at variance with clinically …

Gold(I)‐N‐Heterocyclic Carbene Synthons in Organometallic Synthesis

T Scattolin, G Tonon, E Botter, SG Guillet… - … A European Journal, 2023 - Wiley Online Library
The prominent role of gold‐N‐heterocyclic carbene (NHC) complexes in numerous research
areas such as homogeneous (photo) catalysis, medicinal chemistry and materials science …

Gold-Based Coronands as Hosts for M3+ Metal Ions: Ring Size Matters

SF Sucena, TI Demirer, A Baitullina, A Hagenbach… - Molecules, 2023 - mdpi.com
The controlled, self-assembled synthesis of multinuclear coordination compounds can be
performed via different approaches. Frequently, steric, geometric and/or electronic factors …