Diabetic kidney disease is one of the fastest growing causes of death worldwide. Epigenetic
regulators control gene expression and are potential therapeutic targets. There is functional …

Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside
and outside the immune system. Recent progress in this field underlines the role of TGF-β in …

Diabetic nephropathy (DN) is one of the most common complications associated with
diabetes and characterized by renal microvascular injury along with accelerated synthesis of …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

The transforming growth factor-β (TGF-β) and Wnt/wingless pathways play critical roles in
the specification of cell fate during development and also contribute to cancer formation and …

Transforming growth factor β1 (TGFβ1) plays a crucial role in the induction of the epithelial‐
to‐mesenchymal transition (EMT) in hepatocytes, which contributes to the pathogenesis of …

One of the commonest causes of end‐stage renal disease is diabetic kidney disease (DKD).
Renal fibrosis, characterized by the accumulation of extracellular matrix (ECM) proteins in …

Renal tubular damage occurs early in diabetic nephropathy (DN) and may play a key role in
the progression of kidney disease. E1A binding protein P300 (EP300) gene polymorphism …

Abstract Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that
regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse …

Connective tissue growth factor (CCN2) is a profibrotic factor acting downstream and
independently of TGF-β to mediate renal fibrosis. Although inflammation is often involved in …