AMP‐activated protein kinase: a cellular energy sensor that comes in 12 flavours
FA Ross, C MacKintosh, DG Hardie - The FEBS journal, 2016 - Wiley Online Library
The AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that is
expressed in essentially all eukaryotic cells, suggesting that it arose during early eukaryotic …
expressed in essentially all eukaryotic cells, suggesting that it arose during early eukaryotic …
OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates
PP Singh, H Isambert - Nucleic acids research, 2020 - academic.oup.com
All vertebrates including human have evolved from an ancestor that underwent two rounds
of whole genome duplication (2R-WGD). In addition, teleost fish underwent an additional …
of whole genome duplication (2R-WGD). In addition, teleost fish underwent an additional …
Identification of ohnolog genes originating from whole genome duplication in early vertebrates, based on synteny comparison across multiple genomes
Whole genome duplications (WGD) have now been firmly established in all major eukaryotic
kingdoms. In particular, all vertebrates descend from two rounds of WGDs, that occurred in …
kingdoms. In particular, all vertebrates descend from two rounds of WGDs, that occurred in …
[HTML][HTML] Recent advances in understanding the roles of whole genome duplications in evolution
C MacKintosh, DEK Ferrier - F1000Research, 2017 - ncbi.nlm.nih.gov
Ancient whole-genome duplications (WGDs)—paleopolyploidy events—are key to solving
Darwin's 'abominable mystery'of how flowering plants evolved and radiated into a rich …
Darwin's 'abominable mystery'of how flowering plants evolved and radiated into a rich …
Selective constraints on coding sequences of nervous system genes are a major determinant of duplicate gene retention in vertebrates
The evolutionary history of vertebrates is marked by three ancient whole-genome
duplications: two successive rounds in the ancestor of vertebrates, and a third one specific to …
duplications: two successive rounds in the ancestor of vertebrates, and a third one specific to …
Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution
The Hippo pathway is a central regulator of organ size and a key tumor suppressor via
coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo …
coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo …
Novel genes associated with the development of carotid paragangliomas
AV Snezhkina, EN Lukyanova, MS Fedorova… - Molecular Biology, 2019 - Springer
Carotid paragangliomas (CPGLs) are rare neuroendocrine tumors of the head and
neck.“Germline” and somatic mutations in a number of genes were shown to be associated …
neck.“Germline” and somatic mutations in a number of genes were shown to be associated …
Molecular Evolution of Aryl Hydrocarbon Receptor Signaling Pathway Genes
D Bhalla, V van Noort - Journal of Molecular Evolution, 2023 - Springer
The Aryl hydrocarbon receptor is an ancient transcriptional factor originally discovered as a
sensor of dioxin. In addition to its function as a receptor of environmental toxicants, it plays …
sensor of dioxin. In addition to its function as a receptor of environmental toxicants, it plays …
Insights into biological complexity from simple foundations
We discuss an overtly “simple approach” to complex biological systems borrowing
selectively from theoretical physics. The approach is framed by three maxims, and we show …
selectively from theoretical physics. The approach is framed by three maxims, and we show …
The Hippo pathway origin and its oncogenic alteration in evolution
The Hippo pathway is a central regulator of organ size and a key tumor suppressor via
coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo …
coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo …