Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

The NAD-dependent deacetylase Sir2 was initially identified as a mediator of replicative
lifespan in budding yeast and was subsequently shown to modulate longevity in worms and …

The influence of the gut microbiota on brain chemistry has been convincingly demonstrated
in rodents. In the absence of gut bacteria, the central expression of brain derived neurotropic …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Neurotrophic factors, a family of secreted proteins that support the growth, survival and
differentiation of neurons, have been intensively studied for decades due to the powerful …

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the developing and adult brain. A single-nucleotide …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Abnormal brain-derived neurotrophic factor (BDNF) signaling seems to have a central role in
the course and development of various neurological and psychiatric disorders. In addition …

Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays
an important role in multiple stress-related mental disorders. Although alterations in BDNF in …