The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …

Mathematical modeling has become a valuable tool that strives to complement conventional
biomedical research modalities in order to predict experimental outcome, generate new …

Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to
ensure sufficient exposure for clinical activity while minimizing toxicity. These agents …

It has been proposed that the binding-site barrier (BSB) for antibody-drug conjugates
(ADCs) can be overcome with the help of antibody coadministration. However, broad utility …

We study the discrete and discrete fractional representation of a pharmacokinetics-
pharmacodynamics (PK-PD) model describing tumor growth and anti-cancer effects in …

Imaging response assessment is a cornerstone of patient care and drug development in
oncology. Clinicians/clinical researchers rely on tumor imaging to estimate the impact of new …

Cancer metastasis is the main cause of death in various types of cancer. However, in the
field of pharmacometrics, cancer disease progression models focus on the growth of primary …

Purpose THIOMAB™ drug conjugates (TDCs) with engineered cysteine residues allow site-
specific drug conjugation and defined Drug-to-Antibody Ratios (DAR). In order to help …

Combinations of gemcitabine and trabectedin exert modest synergistic cytotoxic effects on
two pancreatic cancer cell lines. Here, systems pharmacodynamic (PD) models that …

The immune system plays a critical role in preventing cancer development and progression.
However, the complex network of cells and soluble factor that form the tumor …