Chemotherapy is the standard internal medical treatment for cancer. However, the
resistance of cancer cells to nearly all kinds of chemotherapeutic drugs and targeted drugs …

Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …

CD99 is a cell surface protein with unique features and only partly defined mechanisms of
action. This molecule is involved in crucial biological processes, including cell adhesion …

The cell surface molecule CD99 has gained interest because of its involvement in regulating
cell differentiation and adhesion/migration of immune and tumor cells. However, the …

Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) acts as an important
regulator in tumor progression. However, its expression and the underlying mechanism in …

Ewing sarcoma (EWS) is the second most common pediatric bone tumor. The EWS tumor
microenvironment is largely recognized as immune-cold, with macrophages being the most …

In tumour cells, macropinocytosis functions as an amino acid supply route and supports
cancer cell survival and proliferation. Initially demonstrated in oncogenic KRAS-driven …

Gliomas are the most common and malignant primary brain tumors. Various hallmarks of
glioma, including sustained proliferation, migration, invasion, heterogeneity, radio-and …

Background Synthetic indolyl-pyridinyl-propenones (IPPs) induce methuosis, a form of non-
apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized …

The volumes of a cell [cell volume (CV)] and its organelles are adjusted by osmoregulatory
processes. During pinocytosis, extracellular fluid volume equivalent to its CV is incorporated …