Designing antibodies as therapeutics

PJ Carter, A Rajpal - Cell, 2022 - cell.com
Antibody therapeutics are a large and rapidly expanding drug class providing major health
benefits. We provide a snapshot of current antibody therapeutics including their formats …

The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress

JM Sasso, R Tenchov, R Bird, KA Iyer… - Bioconjugate …, 2023 - ACS Publications
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

A review of formulations of commercially available antibodies

RG Strickley, WJ Lambert - Journal of pharmaceutical sciences, 2021 - Elsevier
This review identified 126 commercially available antibodies approved globally between
1986 and February 2021 including 10 antibody drug conjugates, 16 biosimilars, and 3 …

[HTML][HTML] Evinacumab in patients with refractory hypercholesterolemia

RS Rosenson, LJ Burgess… - … England Journal of …, 2020 - Mass Medical Soc
Background Patients with refractory hypercholesterolemia, who have high low-density
lipoprotein (LDL) cholesterol levels despite treatment with lipid-lowering therapies at …

[HTML][HTML] Randomized controlled trial: subcutaneous vs intravenous infliximab CT-P13 maintenance in inflammatory bowel disease

S Schreiber, S Ben-Horin, J Leszczyszyn, R Dudkowiak… - Gastroenterology, 2021 - Elsevier
Background & aims This study compared pharmacokinetics, symptomatic and endoscopic
efficacy, safety, and immunogenicity of a subcutaneous formulation of the infliximab …

Subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (COLUMBA): a multicentre, open-label, non-inferiority …

MV Mateos, H Nahi, W Legiec, S Grosicki… - The lancet …, 2020 - thelancet.com
Background Intravenous daratumumab for treatment of patients with multiple myeloma
involves a lengthy infusion that affects quality of life, and infusion-related reactions are …

[HTML][HTML] A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery

C Yeung, S Chen, B King, H Lin, K King, F Akhtar… - …, 2019 - pubs.aip.org
Embedding microfluidic architectures with microneedles enables fluid management
capabilities that present new degrees of freedom for transdermal drug delivery. To this end …

US FDA-approved therapeutic antibodies with high-concentration formulation: summaries and perspectives

SS Wang, Y Yan, K Ho - Antibody therapeutics, 2021 - academic.oup.com
Thirty four (34) of the total US FDA approved 103 therapeutic antibody drugs, accounts for
one third of the total approved mAbs, are formulated with high protein concentration (100 …

[HTML][HTML] Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment

P Graván, A Aguilera-Garrido, JA Marchal… - Advances in Colloid and …, 2023 - Elsevier
Nanotechnological drug delivery platforms represent a new paradigm for cancer
therapeutics as they improve the pharmacokinetic profile and distribution of …

Polymeric nanofibers for drug delivery applications: a recent review

X Duan, H Chen, C Guo - Journal of Materials Science: Materials in …, 2022 - Springer
With the rapid development of biomaterials and biotechnologies, various functional
materials-based drug delivery systems (DDS) are developed to overcome the limitations of …