Mitochondrial quality control in health and in Parkinson's disease
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …
pivotal organelle, dysfunction of which has been linked to several human diseases including …
Mitochondrial machineries for protein import and assembly
N Wiedemann, N Pfanner - Annual review of biochemistry, 2017 - annualreviews.org
Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …
[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context
M Morgenstern, CD Peikert, P Lübbert, I Suppanz… - Cell metabolism, 2021 - cell.com
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …
control and have been linked to various diseases. Different views exist on the composition of …
Central role of Tim17 in mitochondrial presequence protein translocation
LF Fielden, JD Busch, SG Merkt, I Ganesan, C Steiert… - Nature, 2023 - nature.com
The presequence translocase of the mitochondrial inner membrane (TIM23) represents the
major route for the import of nuclear-encoded proteins into mitochondria,. About 60% of …
major route for the import of nuclear-encoded proteins into mitochondria,. About 60% of …
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol
Most of the mitochondrial proteome originates from nuclear genes and is transported into the
mitochondria after synthesis in the cytosol. Complex machineries which maintain the …
mitochondria after synthesis in the cytosol. Complex machineries which maintain the …
Structure of the mitochondrial import gate reveals distinct preprotein paths
The translocase of the outer mitochondrial membrane (TOM) is the main entry gate for
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …
Role of the TOM complex in protein import into mitochondria: structural views
Y Araiso, K Imai, T Endo - Annual Review of Biochemistry, 2022 - annualreviews.org
Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To
make new mitochondria from preexisting mitochondria, the cell needs to import …
make new mitochondria from preexisting mitochondria, the cell needs to import …
Mitochondrial protein import: from proteomics to functional mechanisms
Mitochondria contain∼ 1,000 different proteins, most of which are imported from the cytosol.
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …
Importing mitochondrial proteins: machineries and mechanisms
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported
across one or both mitochondrial membranes. There is an amazingly versatile set of …
across one or both mitochondrial membranes. There is an amazingly versatile set of …
[HTML][HTML] The protein import machinery of mitochondria—a regulatory hub in metabolism, stress, and disease
Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …
import more than 1,000 different proteins from the cytosol. It had been assumed that the …