Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

Astrocytes undergo an inflammatory transition after infections, acute injuries and chronic
neurodegenerative diseases. How this transition is affected by time and sex, its …

Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Glia constitute roughly half of the cells of the central nervous system (CNS) but were long-
considered to be static bystanders to its formation and function. Here we provide an …

Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …