Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Recent advances in computer vision and machine learning underpin a collection of
algorithms with an impressive ability to decipher the content of images. These deep learning …

How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Cytoplasmic dynein is essential for intracellular transport. Despite extensive in vitro
characterizations, how the dynein motors transport vesicles by processive steps in live cells …

The assembly of sequence-specific enhancer-binding transcription factors (TFs) at cis-
regulatory elements in the genome has long been regarded as the fundamental mechanism …

The contrast between the disruption of genome topology after cohesin loss and the lack of
downstream gene expression changes instigates intense debates regarding the structure …

How pioneer factors interface with chromatin to promote accessibility for transcription control
is poorly understood in vivo. Here, we directly visualize chromatin association by the …

Enzymatic probes of chromatin structure reveal accessible versus inaccessible chromatin
states, while super-resolution microscopy reveals a continuum of chromatin compaction …

How molecules interact governs how they move. Single-molecule tracking (SMT) thus
provides a unique window into the dynamic interactions of biomolecules within live cells …