Impact of COVID-19 in the mental health in elderly: psychological and biological updates
RE Grolli, MED Mingoti, AG Bertollo, AR Luzardo… - Molecular …, 2021 - Springer
Since December 2019, the world has been experiencing the challenge of facing coronavirus
disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS …
disease-19 (COVID-19), a severe infectious disease caused by the new coronavirus, SARS …
Maternal immune activation: Implications for neuropsychiatric disorders
ML Estes, AK McAllister - Science, 2016 - science.org
Epidemiological evidence implicates maternal infection as a risk factor for autism spectrum
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …
disorder and schizophrenia. Animal models corroborate this link and demonstrate that …
Ketamine and depression: a narrative review
A Corriger, G Pickering - Drug design, development and therapy, 2019 - Taylor & Francis
Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …
be reduced within several weeks after the start of conventional antidepressants, but …
Major depressive disorder
Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …
depressed mood, diminished interests, impaired cognitive function and vegetative …
Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant
effects that are thought to be mediated by activation of the mechanistic target of rapamycin …
effects that are thought to be mediated by activation of the mechanistic target of rapamycin …
Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
The molecular mechanisms underlying major depressive disorder remain poorly
understood, and current antidepressant treatments have many shortcomings. The recent …
understood, and current antidepressant treatments have many shortcomings. The recent …
Ketamine: a tale of two enantiomers
The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine,
an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important …
an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important …
[HTML][HTML] The anti-inflammatory role of omega-3 polyunsaturated fatty acids metabolites in pre-clinical models of psychiatric, neurodegenerative, and neurological …
J Giacobbe, B Benoiton, P Zunszain… - Frontiers in …, 2020 - frontiersin.org
Inflammation has been identified as one of the main pathophysiological mechanisms
underlying neuropsychiatric and neurodegenerative disorders. Despite the role of …
underlying neuropsychiatric and neurodegenerative disorders. Despite the role of …
[HTML][HTML] Molecular mechanisms of rapid-acting antidepressants: new perspectives for developing antidepressants
T Chen, L Cheng, J Ma, J Yuan, C Pi, L Xiong… - Pharmacological …, 2023 - Elsevier
Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional
antidepressants usually require several weeks of continuous administration to exert …
antidepressants usually require several weeks of continuous administration to exert …
Eradicating suicide at its roots: preclinical bases and clinical evidence of the efficacy of ketamine in the treatment of suicidal behaviors
D De Berardis, M Fornaro, A Valchera… - International journal of …, 2018 - mdpi.com
Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …