Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Biofunctionalized 3D printed structures for biomedical applications: A critical review of recent advances and future prospects

O Lotz, DR McKenzie, MM Bilek, B Akhavan - Progress in Materials …, 2023 - Elsevier
One of the greatest trends currently revolutionizing healthcare is the introduction of
advanced additive manufacturing techniques, also known as 3D printing, for personalized …

Recent advances in biomaterial-boosted adoptive cell therapy

Y Xue, J Che, X Ji, Y Li, J Xie, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Adoptive immunotherapies based on the transfer of functional immune cells hold great
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …

Application of nano-delivery systems in lymph nodes for tumor immunotherapy

Y Xia, S Fu, Q Ma, Y Liu, N Zhang - Nano-micro letters, 2023 - Springer
Immunotherapy has become a promising research “hotspot” in cancer treatment.“Soldier”
immune cells are not uniform throughout the body; they accumulate mostly in the immune …

Lyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells

J Shi, W Wu, D Chen, Z Liao, T Sheng, Y Wang… - Nature Materials, 2024 - nature.com
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell
priming, activation and tolerance. T cell activity and function are highly regulated by lymph …

New tools for immunologists: models of lymph node function from cells to tissues

T Ozulumba, AN Montalbine… - Frontiers in …, 2023 - frontiersin.org
The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy

A Isser, NK Livingston, JP Schneck - Biomaterials, 2021 - Elsevier
T cells are often referred to as the 'guided missiles' of our immune system because of their
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …

Engineered Bio‐Based Hydrogels for Cancer Immunotherapy

Y Peng, S Liang, QF Meng, D Liu, K Ma… - Advanced …, 2024 - Wiley Online Library
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its
potential to impede tumor metastasis and recurrence. Nonetheless, challenges including …

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

Z Liao, J Jiang, W Wu, J Shi, Y Wang… - National Science …, 2024 - academic.oup.com
The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily
responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional …

Lymph‐Node‐Targeted Drug Delivery for Effective Immunomodulation to Prolong the Long‐Term Survival After Heart Transplantation

YJ Che, XH Ren, ZW Wang, Q Wu, K Xing… - Advanced …, 2023 - Wiley Online Library
The chronic rejection responses and side effects of the systematic administration of
immunosuppressants are the main obstacles to heart allograft and patient survival. The …