Over the past thirty years, researchers have highlighted the role played by a class of proteins
or polypeptides that forms pathogenic amyloid aggregates in vivo, including i) the amyloid …

Human islet amyloid polypeptide (hIAPP), otherwise known as amylin, is a 37-residue
peptide hormone which is reported to be a common factor in protein misfolding disorders …

Pathogenic Rhodococcus equi release the virulence‐associated protein A (VapA) within
macrophage phagosomes. VapA permeabilizes phagosome and lysosome membranes and …

Alzheimer's disease (AD) is one of the leading causes of dementia in elderly people. It has
been well documented that the exposure to environmental toxins such as CO, CO 2, SO 2 …

Studies revolving around mechanisms responsible for the development of amyloid-based
diseases lay the foundations for the recognition of molecular targets of future to-be …

Numerous pathophysiological conditions are associated with the misfolding and
aggregation of proteins into insoluble amyloid fibrils. The mechanisms by which this process …

The formation of amyloid oligomers and fibrils of the human islet amyloid polypeptide
(hIAPP) has been linked with β-cell failure and death which causes the onset, progression …

Background and aims This is the first time that obesity and diabetes mellitus (DM) as protein
conformational diseases (PCD) are reported in children and they are typically diagnosed too …

A hallmark of Alzheimer's, Parkinson's, and other amyloid diseases is the assembly of
amyloid proteins into amyloid aggregates or fibrils. In many cases, the formation and …

The fold of a protein determines its function and its misfolding can result in loss-of-function
defects. In addition, for certain proteins their misfolding can lead to gain-of-function toxicities …