Passing the vascular barrier: endothelial signaling processes controlling extravasation

N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

[HTML][HTML] Endothelial glycocalyx

CA Foote, RN Soares, FI Ramirez-Perez… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

RL Proia, T Hla - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …

An update on the biology of sphingosine 1-phosphate receptors

VA Blaho, T Hla - Journal of lipid research, 2014 - ASBMB
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …

The outs and the ins of sphingosine-1-phosphate in immunity

S Spiegel, S Milstien - Nature Reviews Immunology, 2011 - nature.com
The potent lipid mediator sphingosine-1-phosphate (S1P) is produced inside cells by two
closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a …

Sphingosine 1-phosphate and cancer

NJ Pyne, S Pyne - Nature Reviews Cancer, 2010 - nature.com
There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer.
S1P regulates processes such as inflammation, which can drive tumorigenesis; …

[HTML][HTML] Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology

E Józefczuk, TJ Guzik, M Siedlinski - Pharmacological research, 2020 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke

Y Yang, MT Torbey - Current neuropharmacology, 2020 - ingentaconnect.com
Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology

V Brinkmann - Pharmacology & therapeutics, 2007 - Elsevier
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is critically involved in the
embryonic development of the cardiovascular and central nervous systems. In the adult, S1P …

Extracellular matrix, inflammation, and the angiogenic response

AG Arroyo, ML Iruela-Arispe - Cardiovascular research, 2010 - academic.oup.com
Inflammation and angiogenesis are frequently coupled in pathological situations such as
atherosclerosis, diabetes, and arthritis. The inflammatory response increases capillary …