Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …

Characterizing cell surface receptors mediating viral infection is critical for understanding
viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated …

Antimicrobial resistance (AMR) is currently the most alarming issue for human health. AMR
already causes 700,000 deaths/year. It is estimated that 10 million deaths due to AMR will …

A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and
reducing CMV disease in transplant patients remains a high priority as no approved …

Human cytomegalovirus encodes at least 25 membrane glycoproteins that are found in the
viral envelope 1. While gB represents the fusion protein, two glycoprotein complexes control …

Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry
mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by …

In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …

Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a
leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly …

In the 1970s–1980s, a striking increase in the number of disseminated human
cytomegalovirus (HCMV) infections occurred in immunosuppressed patient populations …