Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

The fundamental role played by neutrophils for an efficient, acute inflammatory response
has long been appreciated, with the underlying molecular and cellular mechanisms largely …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of
chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow …

Since the adult respiratory distress syndrome was first described substantial progress has
been made in understanding the pathogenesis of this complex syndrome. This review …

The primary function of neutrophils in host defense is to contain and eradicate invading
microbial pathogens. This is achieved through a series of swift and highly coordinated …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs) is classified by the World
Health Organization as a disorder of the central nervous system. ME/cfs is an neuro-immune …