Somatic mutations in genes encoding components of the RNA splicing machinery occur
frequently in multiple forms of cancer. The most frequently mutated RNA splicing factors in …

Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

Splicing is a critical processing step during pre-mRNA maturation in eukaryotes. The correct
selection of splice sites during the early steps of spliceosome assembly is highly important …

The spliceosome is a eukaryotic multimegadalton RNA–protein complex that removes
introns from transcripts. The spliceosome ensures the selection of each exon-intron …

The splicing factor RNA-binding motif protein 10 (RBM10) is frequently mutated in lung
adenocarcinoma (LUAD)(9-25%). Most RBM10 cancer mutations are loss-of-function …

The Rbfox proteins regulate alternative pre-mRNA splicing by binding to the RNA element
GCAUG. In the nucleus, most of Rbfox is bound to LASR, a complex of RNA-binding proteins …

Microexons are essential for proper functioning of neurons and pancreatic endocrine cells,
where their inclusion depends on the splicing factors SRRM3/4. However, in pancreatic …

The spliceosome catalyzes the splicing of pre-mRNAs. Although the spliceosome evolved
from a prokaryotic self-splicing intron and an associated protein, it is a vastly more complex …