Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the
underlying mechanism remains nebulous. In this work, we used cryo–electron tomography …

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments
orchestrated by rising and falling Ca2+ levels. Thin filaments are comprised of two actin …

More than a century of research on the Frank–Starling Law has significantly advanced our
knowledge about the working heart. The Frank–Starling Law mandates that the heart is able …

The molecular mechanism by which Ca 2+ binding and phosphorylation regulate muscle
contraction through Troponin is not yet fully understood. Revealing the differences between …

Cardiac contraction depends on molecular interactions among sarcomeric proteins
coordinated by the rising and falling intracellular Ca2+ levels. Cardiac thin filament (cTF) …

Fish and marine invertebrates constitute an important part of the human diet worldwide, and
their muscles are the major edible parts. The muscles are a rich source of proteins, which in …

Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations
to thick and thinfilament proteins. Although thin filament mutations are less prevalent than …

Mutations of cardiac myosin binding protein-C (cMyBP-C) are inherited by an estimated 60
million people worldwide, and the protein is the target of several kinases. Recent evidence …