This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …

In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the
nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly …

The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that
regulates cell-cycle progression and growth by sensing changes in energy status. We …

Behavioral expression of food-associated memory in fruit flies is constrained by satiety and
promoted by hunger, suggesting an influence of motivational state. Here, we identify a …

The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin
signalling in the fly, as in mammals, regulates a number of physiological functions, including …

Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues.
At the same time, proliferation of stem and progenitor cells has to be carefully controlled to …

Insulin has pleiotropic biological effects in virtually all tissues. However, the relevance of
insulin signaling in peripheral tissues has been studied far more extensively than its role in …

Lipid metabolism is essential for growth and generates much of the energy needed during
periods of starvation. In Drosophila, fasting larvae release large quantities of lipid from the …

Animals often decide between alternative actions according to their current needs, and
hence the value they assign to each of the competing options [1–4]. This process is of …