Detection of minimal residual disease (MRD) has proven to provide independent prognostic
information for treatment stratification in several types of leukemias such as childhood acute …

Acute myeloid leukaemia (AML) is an uncontrolled clonal proliferation of abnormal myeloid
progenitor cells in the bone marrow and blood. Advances in cancer genomics have revealed …

Leukemia-specific AML1/ETO transcripts are detectable in most patients with t (8; 21) acute
myelogenous leukemia (AML) in long-term remission. To understand the inconsistency …

The myelodysplastic syndromes are clonal hematologic disorders characterized clinically
and morphologically by ineffective hematopoiesis. The natural history of these syndromes …

Recent reports have established the prenatal origin of leukemia translocations and resultant
fusion genes in some patients, including MLL-AF4 translocations in infants and TEL-AML1 …

The past decade has yielded immense progress in the understanding of the pathogenesis of
acute leukemia. The cloning of consistent chromosomal breakpoints associated with …

Therapy-related acute myeloid leukemia (t-AML) in most cases develops after chemotherapy
of other malignancies and shows characteristic chromosome aberrations. Two general types …

Approximately 40% of children with acute myeloid leukemia (AML) who respond to initial
therapy subsequently relapse. Multidimensional flow cytometry employing a standardized …

The t (8; 21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The
translocation results in an in‐frame fusion of two genes, resulting in a fusion protein of one N …

The leukemia-specific AML1/ETO fusion gene has been shown to be detected by reverse
transcriptase polymerase chain reaction (RT-PCR) analysis in patients with t (8; 21) acute …