Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …

The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

Background Triple negative breast cancer (TNBC), the most aggressive subtype of breast
cancer, is characterized by a high incidence of brain metastasis (BrM) and a poor prognosis …

Background Sustained yet intractable immunosuppression is commonly observed in septic
patients, resulting in aggravated clinical outcomes. However, due to the substantial …

The number of studies investigating the human gastrointestinal tract using various single-
cell profiling methods has increased substantially in the past few years. Although this …

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

Circulating tumor cells (CTCs) hold unique biological characteristics that directly involve
them in hematogenous dissemination. Studying CTCs systematically is technically …

In recent years, advancements in single-cell and spatial transcriptomics, which are highly
regarded developments in the current era, particularly the emerging integration of single-cell …

Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. It is
a whole organ disease characterized by cartilage degeneration and varying degrees of …

In teleost fish, kidney is an important immune and hematopoietic organ with multiple
physiological functions. However, the immune cells and cellular markers of kidney require …