Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

Summary hnRNPA2, a component of RNA-processing membraneless organelles, forms
inclusions when mutated in a syndrome characterized by the degeneration of neurons …

Post-translational modifications (PTMs) produce significant changes in the structural
properties of intrinsically disordered proteins (IDPs) by affecting their energy landscapes …

Intrinsically disordered proteins play important roles in cell signalling, transcription,
translation and cell cycle regulation,. Although they lack stable tertiary structure, many …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Disordered proteins play an essential role in a wide variety of biological processes, and are
often posttranslationally modified. One such protein is histone H1; its highly disordered C …

Determining the functional relationship between Tau phosphorylation and aggregation has
proven a challenge owing to the multiple potential phosphorylation sites and their clustering …

Phosphorylation and dephosphorylation of proteins by kinases and phosphatases are
central to cellular responses and function. The structural effects of serine and threonine …