Improving our understanding of mammalian pancreas development is crucial for the
development of more effective cellular therapies for diabetes. Most of what we know about …

Neonatal diabetes mellitus (NDM) is noted as a genetic, heterogeneous, and rare disease in
infants. NDM occurs due to a single-gene mutation in neonates. A common source for …

Directed differentiation of human pluripotent stem cells (hPSCs) into somatic counterparts is
a valuable tool for studying disease. However, examination of developmental mechanisms …

Finding new causes of monogenic diabetes helps understand glycaemic regulation in
humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we …

Increasing evidence suggests that loss of β cell characteristics may cause insulin secretory
deficiency in diabetes, but the underlying mechanisms remain unclear. Here, we show that …

Perfluorooctanesulfonic acid (PFOS) is a ubiquitous environmental contaminant, previously
utilized as a non-stick application for consumer products and firefighting foam. It can cross …

Development and function of pancreatic β cells involve the regulated activity of specific
transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation …

Abstract Objective Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut
luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy …

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia as a
result of progressive loss of pancreatic β cells, which could lead to several debilitating …

Here, we review how human pluripotent stem cell models of pancreas development have
emerged and became an important tool to study human development and disease. Initially …