Biomolecular damage induced by ionizing radiation: the direct and indirect effects of low-energy electrons on DNA

E Alizadeh, TM Orlando, L Sanche - Annual review of physical …, 2015 - annualreviews.org
Many experimental and theoretical advances have recently allowed the study of direct and
indirect effects of low-energy electrons (LEEs) on DNA damage. In an effort to explain how …

The hydrated electron

JM Herbert, MP Coons - Annual review of physical chemistry, 2017 - annualreviews.org
Existence of a hydrated electron as a byproduct of water radiolysis was established more
than 50 years ago, yet this species continues to attract significant attention due to its role in …

Hydrogen-bond relaxation dynamics: resolving mysteries of water ice

Y Huang, X Zhang, Z Ma, Y Zhou, W Zheng… - Coordination Chemistry …, 2015 - Elsevier
We present recent progress in understanding the anomalous behavior of water ice under
mechanical compression, thermal excitation, and molecular undercoordination (with fewer …

Low-energy shape resonances of a nucleobase in water

GA Cooper, CJ Clarke, JRR Verlet - Journal of the American …, 2022 - ACS Publications
When high-energy radiation passes through aqueous material, low-energy electrons are
produced which cause DNA damage. Electronic states of anionic nucleobases have been …

Microhydration prevents fragmentation of uracil and thymine by low-energy electrons

J Kocisek, A Pysanenko, M Fárník… - The Journal of Physical …, 2016 - ACS Publications
When ionizing radiation passes biological matter, a large number of secondary electrons
with very low energies (< 3 eV) is produced. It is known that such electrons cause an efficient …

Reaction of electrons with DNA: radiation damage to radiosensitization

A Kumar, D Becker, A Adhikary, MD Sevilla - International Journal of …, 2019 - mdpi.com
This review article provides a concise overview of electron involvement in DNA radiation
damage. The review begins with the various states of radiation-produced electrons …

Radiation damage to DNA: The indirect effect of low-energy electrons

E Alizadeh, AG Sanz, G Garcia… - The journal of physical …, 2013 - ACS Publications
We report the effect of the DNA hydration level on damage yields induced by soft X-rays and
photoemitted low-energy electrons (LEEs) in thin films of plasmid DNA irradiated in N2 at …

Reactivity of prehydrated electrons toward nucleobases and nucleotides in aqueous solution

J Ma, F Wang, SA Denisov, A Adhikary… - Science advances, 2017 - science.org
DNA damage induced via dissociative attachment by low-energy electrons (0 to 20 eV) is
well studied in both gas and condensed phases. However, the reactivity of ultrashort-lived …

Observation of dissociative quasi-free electron attachment to nucleoside via excited anion radical in solution

J Ma, A Kumar, Y Muroya, S Yamashita… - Nature …, 2019 - nature.com
Damage to DNA via dissociative electron attachment has been well-studied in both the gas
and condensed phases; however, understanding this process in bulk solution at a …

Mechanisms of damage to DNA labeled with electrophilic nucleobases induced by ionizing or UV radiation

J Rak, L Chomicz, J Wiczk, K Westphal… - The Journal of …, 2015 - ACS Publications
Hypoxia a hallmark of solid tumors makes hypoxic cells radioresistant. On the other
hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons …