Lung cancer is the leading cause of cancer-related death worldwide. However, lung cancer
incidence and mortality rates differ substantially across the world, reflecting varying patterns …

Background: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of
developing several common cancers, but it is unclear whether this association is causal. We …

Abstract The American Cancer Society (ACS) publishes the Diet and Physical Activity
Guideline to serve as a foundation for its communication, policy, and community strategies …

We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …

At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung
cancer risk, which may reflect reverse causality and confounding due to smoking behavior …

Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains
unclear whether there are similar causal effects of obesity traits on other non-communicable …

Leptin is a nutritional cytokine, and it is closely related to the progression of cancer.
However, the detailed effect of leptin in lung cancer remains poorly known. We found leptin …

We conducted a two-sample Mendelian randomization study to investigate the causal
associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer and 22 site …

The burden of cancer from a clinical, societal, and economic viewpoint continues to increase
in all parts of the world, along with much debate regarding how to confront this. Projected …

Observational epidemiologic studies are prone to confounding, measurement error, and
reverse causation, undermining robust causal inference. Mendelian randomization (MR) …