The biofilm life cycle: expanding the conceptual model of biofilm formation

K Sauer, P Stoodley, DM Goeres… - Nature Reviews …, 2022 - nature.com
Bacterial biofilms are often defined as communities of surface-attached bacteria and are
typically depicted with a classic mushroom-shaped structure characteristic of Pseudomonas …

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

O Ciofu, T Tolker-Nielsen - Frontiers in microbiology, 2019 - frontiersin.org
Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Bacterial biofilms predominate in both acute and chronic human lung infections

M Kolpen, KN Kragh, JB Enciso, D Faurholt-Jepsen… - Thorax, 2022 - thorax.bmj.com
Background A basic paradigm of human infection is that acute bacterial disease is caused
by fast growing planktonic bacteria while chronic infections are caused by slow-growing …

The in vivo biofilm

T Bjarnsholt, M Alhede, M Alhede… - Trends in …, 2013 - cell.com
Bacteria can grow and proliferate either as single, independent cells or organized in
aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm …

Phage therapy as an alternative or complementary strategy to prevent and control biofilm-related infections

DP Pires, LDR Melo, DV Boas, S Sillankorva… - Current opinion in …, 2017 - Elsevier
Highlights•Interaction of phages and biofilm cells depends on phage-host characteristics
and biofilm structure.•Biofilm features (eg matrix, cell metabolic state, resistant variants) …

Applying insights from biofilm biology to drug development—can a new approach be developed?

T Bjarnsholt, O Ciofu, S Molin, M Givskov… - Nature reviews Drug …, 2013 - nature.com
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …

In vitro and in vivo model systems to study microbial biofilm formation

T Coenye, HJ Nelis - Journal of microbiological methods, 2010 - Elsevier
Biofilm formation is often considered the underlying reason why treatment with an
antimicrobial agent fails and as an estimated 65–80% of all human infections is thought to …

[HTML][HTML] Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms

M Fernández-Billón, AE Llambías-Cabot… - Biofilm, 2023 - Elsevier
Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long
lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic …

Biofilms as living catalysts in continuous chemical syntheses

B Halan, K Buehler, A Schmid - Trends in biotechnology, 2012 - cell.com
Biofilms are resilient to a wide variety of environmental stresses. This inherited robustness
has been exploited mainly for bioremediation. With a better understanding of their …

Functional single-cell analyses: flow cytometry and cell sorting of microbial populations and communities

S Müller, G Nebe-von-Caron - FEMS Microbiology reviews, 2010 - academic.oup.com
The still poorly explored world of microbial functioning is about to be uncovered by a
combined application of old and new technologies. Bacteria, especially, are still in the dark …