Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …

At present chronic liver disease (CLD), the third commonest cause of premature death in the
United Kingdom is detected late, when interventions are ineffective, resulting in …

Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …

Liver natural killer and natural killer T cells not only play a critical role in anti–viral and anti–
tumor defenses but also contribute to the pathogenesis of chronic liver diseases. Hepatic …

Innate immune system is the first line of defence against invading pathogens that is critical
for the overall survival of the host. Human liver is characterised by a dual blood supply, with …

The cellular composition of visceral adipose tissue (VAT) and release of cytokines by such
cells within VAT has been implicated in regulating obesity and metabolic homeostasis. We …

Liver fibrosis is a common scarring response to all forms of chronic liver injury and is always
associated with inflammation that contributes to fibrogenesis. Although a variety of cell …

Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens
in the context of the MHC class I-related glycoprotein CD1d. Recent studies have identified …

Natural killer T (NKT) cells are a unique subset of lymphocytes that express NK cell markers
such as CD161 and CD94, as well as a T-cell receptor (TCR) α/β, with a restricted repertoire …

Rationale: Hypersensitivity pneumonitis (HP) exhibits a diverse outcome. Patients with
acute/subacute HP usually improve, whereas patients with chronic disease often progress to …