The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Phosphonates, often used as isosteric replacements for phosphates, can provide important
interactions with an enzyme. Due to their high charge at physiological pH, however …

Prenyltransferases (PTases) are known to play a role in embryonic development, normal
tissue homeostasis and cancer by posttranslationally modifying proteins involved in these …

Germinal centres are important sites for antibody diversification and affinity maturation, and
are also a common origin of B cell malignancies. Despite being made up of motile cells …

Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis
pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP). GGPP …

The mevalonate (MVA) pathway is often dysregulated or overexpressed in many cancers
suggesting tumor dependency on this classic metabolic pathway. Statins, which target the …

Drug resistance, metastasis, and a mesenchymal transcriptional program are central
features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is …

Background The ultrahigh density intensive farming model of grass carp
(Ctenopharyngodon idellus) may elicit growth inhibition, decrease flesh quality, and …